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Dr. Juan Carlos Zenteno Ruíz

E-mail: cayguash @ yahoo.com
+52 (55)

SNI II
Profesor Titular “A” de Medio Tiempo
Doctor en Ciencias Médicas


Líneas de investigación

Inmunogenética, análisis molecular en enfermedades hereditarias humanas, análisis genómico, malformaciones congénitas.

Proyectos

  • Identificación de variantes genéticas de riesgo para uveítis autoinmunes
  • Identificación de regiones de ligamiento a genoma completo con microarreglos de DNA
  • Caracterización de mutaciones génicas causantes de ceguera hereditaria
  • Identificación de polimorfismos genéticos que confieren riesgo para el desarrollo de retinopatía diabética

Publicaciones Recientes

  1. Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept. Dinculescu A, Estreicher J, Zenteno JC, Aleman TS, Schwartz SB, Huang WC, Roman AJ, Sumaroka A, Li Q, Deng WT, Min SH, Chiodo VA, Neeley A, Liu X, Shu X, Matias-Florentino M, Buentello-Volante B, Boye SL, Cideciyan AV, Hauswirth WW, Jacobson SG. Hum Gene Ther. 2012;23:367-376
  2. Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population. Jaimes M, Rivera-Parra D, Miranda-Duarte A, Valdés G, Zenteno JC. Ophthalmic Genet. 2012;33:12-17.

Immunophenotyping in peripheral blood mononuclear cells, aqueous humour and vitreous in a Blau syndrome patient caused by a novel NOD2 mutation. Jimenez-Martinez MC, Cruz F, Groman-Lupa S, Zenteno JC. Int J Immunogenet. 2011;38:233-242.

  1. Mutations in a novel serine protease PRSS56 in families with nanophthalmos. Orr A, Dubé MP, Zenteno JC, Jiang H, Asselin G, Evans SC, Caqueret A, Lakosha H, Letourneau L, Marcadier J, Matsuoka M, Macgillivray C, Nightingale M, Papillon-Cavanagh S, Perry S, Provost S, Ludman M, Guernsey DL, Samuels ME. Mol Vis. 2011;17:1850-1861.
  2. Homozygosity mapping identifies the Crumbs homologue 1 (Crb1) gene as responsible for a recessive syndrome of retinitis pigmentosa and nanophthalmos. Zenteno JC, Buentello-Volante B, Ayala-Ramirez R, Villanueva-Mendoza C. Am J Med Genet A. 2011;155A:1001-1006.
  3. Homozygous FOXE3 mutations cause non-syndromic, bilateral, total sclerocornea, aphakia, microphthalmia and optic disc coloboma. Ali M, Buentello-Volante B, McKibbin M, Rocha-Medina JA, Fernandez-Fuentes N, Koga-Nakamura W, Ashiq A, Khan K, Booth AP, Williams G, Raashid Y, Jafri H, Rice A, Inglehearn CF, Zenteno JC. Mol Vis. 2010;16:1162-1168.
  4. Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases. Gonzalez-Rodriguez J, Pelcastre EL, Tovilla-Canales JL, Garcia-Ortiz JE, Amato-Almanza M, Villanueva-Mendoza C, Espinosa-Mattar Z, Zenteno JC. Br J Ophthalmol. 2010;94:1100-1104.
  5. Molecular screening of rhodopsin and peripherin/RDS genes in Mexican families with autosomal dominant retinitis pigmentosa. Matias-Florentino M, Ayala-Ramirez R, Graue-Wiechers F, Zenteno JC. Curr Eye Res. 2009;34:1050-1056.
  6. Clinical and genetic features of TGFBI-linked corneal dystrophies in Mexican population: description of novel mutations and novel genotype-phenotype correlations. Zenteno JC, Correa-Gomez V, Santacruz-Valdez C, Suarez-Sanchez R, Villanueva-Mendoza C. Exp Eye Res. 2009;89:172-177.
  7. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Miyake N, Chilton J, Psatha M, Cheng L, Andrews C, Chan WM, Law K, Crosier M, Lindsay S, Cheung M, Allen J, Gutowski NJ, Ellard S, Young E, Iannaccone A, Appukuttan B, Stout JT, Christiansen S, Ciccarelli ML, Baldi A, Campioni M, Zenteno JC, Davenport D, Mariani LE, Sahin M, Guthrie S, Engle EC. Science. 2008;321(5890):839-843.
  8. Contribution of CYP1B1 mutations and founder effect to primary congenital glaucoma in Mexico. Zenteno JC, Hernandez-Merino E, Mejia-Lopez H, Matías-Florentino M, Michel N, Elizondo-Olascoaga C, Korder-Ortega V, Casab-Rueda H, Garcia-Ortiz JE. J Glaucoma. 2008;17:189-192
  9. Two different PABPN1 expanded alleles in a Mexican population with oculopharyngeal muscular dystrophy arising from independent founder effects. Rivera D, Mejia-Lopez H, Pompa-Mera EN, Villanueva-Mendoza C, Nava-Castañeda A, Garnica-Hayashi L, Cuevas-Covarrubias S, Zenteno JC. Br J Ophthalmol. 2008;92:998-1002.